Publikationen

Ros, Uris ; Martinez-Osorio, Veronica ; Valiente, Pedro A. ; Abdelwahab, Yasmin ; Gojkovic, Milos ; Shalaby, Raed ; Zanna, Silvia ; Saggau, Julia ; u. a.: MLKL activity requires a splicing-regulated, druggable intramolecular interaction. In: Molecular Cell (2025)

Posor, York ; Conduit, Sarah E. ; Pearce, Wayne ; Morelli, Daniele ; Constantinou, Georgia ; Whitehead, Maria ; Sebire, Neil J. ; Scudamore, Cheryl L. ; u. a.: Inactivation of PI3K-C2α deregulates cell death pathways and sensitizes to endotoxic shock. In: Proceedings of the National Academy of Sciences (2025)

H, Kaul ; L, Isermann ; K, Senft ; M, Popovic ; T, Georgomanolis ; L, Baumann ; P, Sivanesan ; A, Pouikli ; u. a.: 2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction. In: Nature metabolism (2025)

Hildebrandt, Ximena ; Veli, Önay ; Hyoubi, Armel ; Zinngrebe, Julia ; Abdallah, Ali T. ; Rodefeld, Julian ; Hoffmann, Anne ; Gardeweg, Liane ; u. a.: Linear ubiquitination prevents lipodystrophy and obesity-associated metabolic syndrome. In: Science Advances Bd. 11, American Association for the Advancement of Science (AAAS) (2025)

Capuccino, L. Valdez ; Kleitke, T. ; Szokol, B. ; Svajda, L. ; Martin, F. ; Bonechi, F. ; Krekó, M. ; Azami, S. ; u. a.: CDK9 inhibition as an effective therapy for small cell lung cancer. In: Cell Death & Disease (2024)

Oda, Hirotsugu ; Manthiram, Kalpana ; Chavan, Pallavi Pimpale ; Rieser, Eva ; Veli, Önay ; Kaya, Öykü ; Rauch, Charles ; Nakabo, Shuichiro ; u. a.: Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency. In: Nature Immunology (2024)

Chen, Yu-Guang ; Rieser, Eva ; Bhamra, Amandeep ; Surinova, Silvia ; Kreuzaler, Peter ; Ho, Meng-Hsing ; Tsai, Wen-Chiuan ; Peltzer, Nieves ; u. a.: LUBAC enables tumor-promoting LTβ receptor signaling by activating canonical NF-κB. In: Cell Death & Differentiation (2024)

Albert, Marie-Christine ; Uranga-Murillo, Iratxe ; Arias, Maykel ; Miguel, Diego De ; Peña, Natacha ; Montinaro, Antonella ; Varanda, Ana Beatriz ; Theobald, Sebastian J. ; u. a.: Identification of FasL as a crucial host factor driving COVID-19 pathology and lethality. In: Cell Death & Differentiation (2024)

Veli, Önay ; Kaya, Öykü ; Varanda, Ana Beatriz ; Hildebrandt, Ximena ; Xiao, Peng ; Estornes, Yann ; Poggenberg, Matea ; Wang, Yuan ; u. a.: RIPK1 is dispensable for cell death regulation in β-cells during hyperglycemia. In: Molecular Metabolism (2024)

Lagunas, Kristel Martinez ; Savcigil, Deniz Pinar ; Zrilic, Matea ; Fraile, Carlos Carvajal ; Craxton, Andrew ; Self, Emily ; Uranga-Murillo, Iratxe ; de Miguel, Diego ; u. a.: Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair. In: Science Advances (2023)

Schorn, Fabian ; Werthenbach, J Paul ; Hoffmann, Mattes ; Daoud, Mila ; Stachelscheid, Johanna ; Schiffmann, Lars M ; Hildebrandt, Ximena ; Lyu, Su Ir ; u. a.: <scp>cIAPs</scp> control <scp>RIPK1</scp> kinase activity‐dependent and ‐independent cell death and tissue inflammation. In: The EMBO Journal (2023)

Hildebrandt, Ximena ; Ibrahim, Mohamed ; Peltzer, Nieves: Cell death and inflammation during obesity: “Know my methods, WAT(son)”. In: Cell Death & Differentiation (2023)

Peltzer, Nieves: Linear ubiquitin as a common regulator of cellular stress. In: The FEBS Journal (2022)

Peltzer, Nieves ; Annibaldi, Alessandro: Cell Death-Related Ubiquitin Modifications in Inflammatory Syndromes: From Mice to Men. In: Biomedicines (2022)

N, Peltzer ; H, Walczak: Cell Death and Inflammation - A Vital but Dangerous Liaison. In: Trends in immunology (2019)

N, Peltzer ; H, Walczak: Endothelial Cell Killing by TAK1 Inhibition: A Novel Anti-angiogenic Strategy in Cancer Therapy. In: Developmental cell (2019)

G, Liccardi ; L, Ramos Garcia ; T, Tenev ; A, Annibaldi ; AJ, Legrand ; D, Robertson ; R, Feltham ; H, Anderton ; u. a.: RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation. In: Molecular cell (2019)

N, Peltzer ; M, Darding ; A, Montinaro ; P, Draber ; H, Draberova ; S, Kupka ; E, Rieser ; A, Fisher ; u. a.: LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis. In: Nature (2018)

L, Taraborrelli ; N, Peltzer ; A, Montinaro ; S, Kupka ; E, Rieser ; T, Hartwig ; A, Sarr ; M, Darding ; u. a.: LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L. In: Nature communications (2018)

E, Giampazolias ; B, Zunino ; S, Dhayade ; F, Bock ; C, Cloix ; K, Cao ; A, Roca ; J, Lopez ; u. a.: Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency. In: Nature cell biology (2017)

Y, Shimizu ; N, Peltzer ; A, Sevko ; E, Lafont ; A, Sarr ; H, Draberova ; H, Walczak: The Linear ubiquitin chain assembly complex acts as a liver tumor suppressor and inhibits hepatocyte apoptosis and hepatitis. In: Hepatology (Baltimore, Md.) (2017)

N, Peltzer ; M, Darding ; H, Walczak: Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling. In: Trends in cell biology (2016)

G, Vanli ; N, Peltzer ; G, Dubuis ; C, Widmann: The activity of the anti-apoptotic fragment generated by the caspase-3/p120 RasGAP stress-sensing module displays strict Akt isoform specificity. In: Cellular signalling (2014)

J, Zinngrebe ; A, Montinaro ; N, Peltzer ; H, Walczak: Ubiquitin in the immune system. In: EMBO reports (2014)

N, Peltzer ; E, Rieser ; L, Taraborrelli ; P, Draber ; M, Darding ; B, Pernaute ; Y, Shimizu ; A, Sarr ; u. a.: HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death. In: Cell reports (2014)

JA, Rickard ; H, Anderton ; N, Etemadi ; U, Nachbur ; M, Darding ; N, Peltzer ; N, Lalaoui ; KE, Lawlor ; u. a.: TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice. In: eLife (2014)

N, Peltzer ; G, Vanli ; JY, Yang ; C, Widmann: Role of mTOR, Bad, and Survivin in RasGAP Fragment N-Mediated Cell Protection. In: PloS one (2013)

N, Peltzer ; P, Bigliardi ; C, Widmann: UV-B induces cytoplasmic survivin expression in mouse epidermis. In: Journal of dermatological science (2012)

H, Khalil ; N, Peltzer ; J, Walicki ; JY, Yang ; G, Dubuis ; N, Gardiol ; W, Held ; P, Bigliardi ; u. a.: Caspase-3 protects stressed organs against cell death. In: Molecular and cellular biology (2012)

N, Bulat ; E, Jaccard ; N, Peltzer ; H, Khalil ; JY, Yang ; G, Dubuis ; C, Widmann: RasGAP-derived fragment N increases the resistance of beta cells towards apoptosis in NOD mice and delays the progression from mild to overt diabetes. In: PloS one (2011)