Genomeditierung

Frau Jun.-Prof. M. Nieves Peltzer

Ausrichtung

Die schnell voranschreitende Entwicklung neuartiger Strategien zur Genomeditierung verändert das Feld der biomedizinischen Forschung und deren Anwendung in hohem Tempo. Die Professur für Genomeditierung soll den Bereich der biomedizinischen Genomeditierung mit innovativen Forschungsthemen abdecken. Insbesondere sollen neuartige Methoden entwickelt und validiert werden. Themengebiete könnten die Therapie von Krebs, die Behandlung von Erbkrankheiten oder die regenerative Medizin sein.

  1. Peer-reviewed articles as senior author
    1. Veli, Ö., Hildebrandt, X., Kaya, Ö., Xiao, P., Estornes, Y., Pasparakis, M., Walczak, H., Bertrand, J.M., Cardozo, K. A. and Peltzer, N. RIPK1 is dispensable for cell death regulation in β-cells. Molecular Metabolism 8, 101988. 2024
    2. Valdez Capuccino L., Kleitke T., Bonechi F., Montinaro A., Wang Y., Kaiser, L., George J., Szokol B., Krekó M., Őrfi L., Gianmaria Liccardi, Walczak H., Brägelmann J., Sos M., Peltzer N. Dinaciclib as an effective therapy for small cell lung cancer. Cell Death and Disease 15(5), 345, 2024
    3. Chen, YG., Rieser, E., Bhamra, A., Surinova, S., Kreuzaler, P., Ho, MH., Tsai, WC., Peltzer, N.*, de Miguel, D.*, and Walczak, H*. LUBAC enables tumor promoting LTβ receptor signaling in cancer cells by activating canonical NF-κB. Cell Death and Differentiation 31, 1267–1284, 2024 (*equal contribution)
    4. Oda, H., Manthiram, K., Chavan, P. P., Rieser, E., Veli, Ö., Kaya, Ö., Rauch, C., Nakabo, S., Kuehn, H. S., Swart, M., Wang, Y., Çelik, N. I., Molitor, A., Ziaee, V., Movahedi, N., Shahrooei, M., Parvaneh, N., Alipour-olyei, N., Carapito, R., Xu, Q., Preite, S., Beck, D. B., Chae, J. J., Nehrebecky, M., Ombrello, A. K., Hoffmann, P., Romeo, T., Deuitch, N. T., Matthíasardóttir, B., Mullikin, J., Komarow, H., Stoddard, J., Niemela, J., Dobbs, K., Sweeney, C. L., Anderton, H., Lawlor, K. E., Yoshitomi, H., Yang, D., Boehm, M., Davis, J., Mudd, P., Randazzo, D., Tsai, W. L., Gadina, M., Kaplan, M. J., Toguchida, J., Mayer, C. T., Rosenzweig, S. D., Notarangelo, L. D., Iwai, K., Silke, J., Schwartzberg, P. L., Boisson, B., Casanova, J.-L., Bahram, S., Rao, A. P., Peltzer, N., Walczak, H., Lalaoui, N., Aksentijevich, I., and Kastner, D. L. (2024) Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency. Nature Immunology 25(5):764-777, 2024
    5. Lagunas K., Savcigil, P, Zrilic, M, Carvajal Fraile, C., Craxton, A., Self, E., Uranga-Murillo I., de Miguel, D., Arias, M., Willenborg, S., Piekarek, M., Albert, MC., Nugraha, K., Lisewski, I., Janakova, E., Igual, N., Tonnus, W., Hildebrandt, X., Ibrahim, I., Ballegeer, M., Saelens, X., Kueh, A, Meier, P., Linkermann, A., Pardo, J., Eming, S., Walczak, H., MacFarlane, M., Peltzer, N., and Annibaldi, A. Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair. Science Advances 9, 10.1126. 2023
    6. Schorn, F. et al. Peltzer, N., Quaas, A., Vucic, D., Silke, J., Pasparakis, M., Kashkar, H. cIAPs control RIPK1 kinase activity-dependent and -independent cell death and tissue inflammation. EMBO J 42, e113614.

  2. Peer-reviewed articles as first author
    1. Taraborrelli, L*., Peltzer, N*., Montinaro, A., Kupka, S., Rieser, E., Hartwig, T., Sarr, A., Darding, D., Draber, P., Haas, T.L., Akarca, A., Marafioti, T., Pasparakis, M., Bertin, J., Gough, P.J., Bouillet, P., Strasser, A., Leverkus, M., Silke, S., Walczak, H. LUBAC prevents lethal dermatitis by combined inhibition of TNF-, TRAIL- and CD95L-mediated cell death. Nature Communications 9:3910, 2018
      *co-first authors
    2. Peltzer, N.*, Darding, M. *, Montinaro, A., Draber, P., Draberova, H., Kupka, S., Rieser, E., Fisher, A., Hutchinson, C., Taraborrelli, L., Hartwig, t., Lafont, E., Haas, T.L., Shimizu, Y., Böiers, C., Sarr, A., Rickard, J., Alvarez-Diaz, S., Ashworth, M.T., Beal, A., Enver, T., Bertin, J., Kaiser, W., Strasser, A., Silke, J., Bouillet, P., Walczak, H.  LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis. Nature 557: 112–117, 2018.
      *co-first authors
    3. Peltzer, N*., Rieser, E.*, Taraborrelli, L., Draber, P., Darding, M., Pernaute, B., Shimizu, Y., Daboh, A., Draberova, H., Montinaro, A., Martinez-Barbera, J.P., Silke, J., Rodriguez, T.A. and Walczak, H. HOIP deficiency caused embryonic lethality by aberrant TNFR1-mediated endothelial cell death. Cell Reports 9: 153-165, 2014
      *co-first authors

  3. Peer-reviewed Collaborations

    1. Albert, M. C., Uranga-Murillo, I., Arias, M., De Miguel, D., Peña, N., Montinaro, A., Varanda, A. B., Theobald, S. J., Areso, I., Saggau, J., Koch, M., Liccardi, G., Peltzer, N., Rybniker, J., Hurtado-Guerrero, R., Merino, P., Monzón, M., Badiola, J. J., Reindl-Schwaighofer, R., Sanz-Pamplona, R., Cebollada-Solanas, A., Megyesfalvi, Z., Dome, B., Secrier, M., Hartmann, B., Bergmann, M., Pardo, J., and Walczak, H. (2024) Identification of FasL as a crucial host factor driving COVID-19 pathology and lethality. Cell Death Differ (doi: 10.1038/s41418-024-01278-6)
    2. Liccardi, G.,  Ramos Garcia, L., Tenev, T., Annibaldi, A.,  Legrand, AJ., Robertson, D, Feltham, F., Anderton, H., Darding, M., Peltzer, N, Dannappel, M.,  Schünke, H.,Fava, L., Haschka, M.D., Glatter, T, Nesvizhskii, T., Schmidt, A., Harris, P.A.,  Bertin, J., Gough, P., Villunger, A., Silke, J., Pasparakis, M., Bianchi, K. and Meier, P. RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation. Molecular Cell 73, 11.010, 2019.
    3. Giampazolias, E., Zunino, B., Dhayade, S., Bock, F., Cloix, C., Cao, K., Roca, A., Lopez, J., Ichim, G., Proïcs, E., Rubio-Patiño, C., Fort, L., Yatim, N., Woodham, E., Orozco, S., Taraborrelli, L., Peltzer, N., Lecis, D., Machesky, L., Walczak, H., Albert, ML., Milling, S., Oberst, A., Ricci, JE., Ryan, KM., Blyth, K., Tait, SWG. Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency. Nat Cell Biol 19(9): 1116-1129, 2017.
    4. Shimizu, Y., Peltzer, N., Sevko, A., Lafont, E., Sarr, A., Draberova, H., Walczak, H. The linear ubiquitin chain assembly complex acts as a liver tumour suppressor and inhibits hepatocyte apoptosis and hepatitis. Hepatology 65(6): 1963-1978, 2017.
    5. Zinngrebe, J., Rieser, E., Taraborrelli, L., Peltzer, N., Hartwig, T., Ren, H., Kovács, I., Endres, C., Draber, P., Darding, M., Karstedt, S., Lemke, J., Dome, B., Bergmann, M., Ferguson, B., Walczak, H. LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation. The Journal of Experimental Medicine 213(12):2671-2689, 2016
    6. Rickard, JA., Anderton, H., Etemadi, N., Nachbur, U., Darding, M., Peltzer, N., Lalaoui, N., Lawlor, KE., Vanyai, H., Hall, C., Bankovacki, A., Gangoda, L., Wei-Lynn Wong, W., Corbin, J., Huang, C., Mocarski, ES., Murphy, JM., Alexander, WS., Voss, AK., Vaux, DL., Kaiser, WJ., Walczak, H., Silke, J. TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice. Elife 2;3, 2014

  4. Reviews, comments and book chapters
    1. Veli, Ö., Peltzer, N. Life and Death of Pancreatic β-cells. Encyclopedia of Cell Biology, Second Edition 6, 19-26 (2023).
    2. Hildebrandt, X., Ibrahim, M. & Peltzer, N. Cell death and inflammation during obesity: "Know my methods, WAT(son)". Cell Death Differ, 1-14, doi:10.1038/s41418-022-01062-4 (2022).
    3. Peltzer, N* and Annibaldi, A*. Cell Death-Related Ubiquitin Modifications in Inflammatory Syndromes: From Mice to Men. Biomedicines, doi:10.3390/biomedicines10061436 (2022) (*co-corresponding authors)
    4. Peltzer, N. Linear ubiquitin as a common regulator of cellular stress. The FEBS journal, doi:10.1111/febs.16427 (2022).
    5. Peltzer, N.*, and Walczak, H*. Cell Death and Inflammation - A Vital but Dangerous Liaison. Trends in immunology (IF: 13) 40, 387-402, 2019 
      *co-corresponding authors
    6. Peltzer, N., and Walczak, H. Endothelial Cell Killing by TAK1 Inhibition: A Novel Anti-angiogenic Strategy in Cancer Therapy. Developmental Cell (IF: 9.6) 48(2):127-128, 2019
    7. Peltzer N, Darding M, Walczak H. Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling. Trends Cell Biol (IF: 13.5) 26(6):445-61, 2016
    8. Zinngrebe, J*., Montinaro, A*., Peltzer, N*. & Walczak, H. Ubiquitin in the immune system. EMBO Rep (IF: 8.38), 15, 28-45, 2014 *co-first authors

  5. Patents
    1. “Combination Therapeutics” UCL Business PLC; Filed: 22/01/18, Inventors: Henning Walczak, Lucia Taraborrelli* and Nieves Peltzer* (*equal contribution). WO 2019/141862 A1
    2. “Modulation of Mixed Lineage Kinase Domain-like Protein Signaling” UCL Business PLC/University of Tübingen. Filed: 05/08/20. Inventors: Ana Garcia Saez… Henning Walczak* and Nieves Peltzer* (*equal contribution). WO 2021/224505A1
    3. Therapeutic treatment: “A method for treating diseases of acute organ failure, including those caused by airway targeting viruses, such as acute respiratory distress syndrome (ARDS), and related diseases”. Filed 10/09/2020. Inventors: Henning Walczak, …, Nieves Peltzer (major contribution). WO 2022/074236 A2

 

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