Research Consortia
The Peltzer Lab participates in several externally funded, multi-institutional research consortia that bring together complementary expertise to tackle complex questions in metabolism, inflammation, cell death, and cancer.
Danger Hep - FOR5889
Keywords: Adipose tissue–liver crosstalk, linear ubiquitination (LUBAC), NF-κB signaling, cell death,
MASLD/MASH, HCC
Methods: Mouse genetics, intravital 2-photon microscopy, WAT explants, PCLS, transcriptomics,
proteomics, lipidomics
SFB1403 – Cell Death in Immunity, Inflammation and Disease
Keywords: cell death, LUBAC, obesity, inflammation, TNF, linear ubiquitination
Methods: transcriptomics, proteomics, Mouse genetics, obesity models, immune-profiling, clinical
diagnosis, metabolic measuring, explants
SFB1399 – Mechanisms of drug sensitivity in Small Cell Lung Cancer (SCLC)
Keywords: SCLC, cancer, pyroptosis, chemotherapy, immunogenic cell death
Methods: transcriptomics, mouse models, biochemistry, molecular biology
GRK3112 EpiSignal - Research Training Group
Keywords: epigenetics, chromatin, cell signaling, DNA methylation
Methods: cell biology, molecular biology, proteomics, transcriptomics, bioinformatics
Research Projects
Beyond consortium-based collaborations, we pursue independent research projects that investigate fundamental biological mechanisms underlying disease.
Wilhelm Sander Stiftung - Therapeutic potential of the epigenetic regulation of pyroptosis in small cell lung cancer
Keywords: SCLC, epigenetics, immunity, gasdermins, immunogenic cell death, mitochondria
Methods: organoids, transcriptomics, drug screen, CRISPR-Cas gene editing, combinatorial targeted
therapy
Contact
Nieves Peltzer
Jun.- Prof. Dr.Director of the Department Genome Editing